I use a intuos 5 in aseprite and get decent results but definitely would like pressure sensitivity for when I have to draw larger things (200x200 is a common size). Sometimes I temporarily paste an item into clip studio paint to add details that benefit from pressure support, but that program doesn’t like being pasted into! And of course something with multiple layers is tricky to do that with anyway. Aseprite’s animation interface is vastly superior to clip stupido’s, in any event.