Is it possible to generate Palette Colors with a Preset?

[sugargenix]

I don’t completely follow. Aseprite can make palettes based on the sprite. You can also save palettes as presets.

You can create some palettes using the gradient tool then shrinking it:

There is also certain tools like: Magic Pencil for Aseprite by Kacper Woźniak
that may help you in making hue shifts. (I thought there was a shortcut but couldn’t find it, although it may have been a tool).

The following may also help:

How do I change Hue, Saturation & Values for entire Color Palettes & how do I add them to the Index and/or make new Indexes?

[Thanks Miura] This one had to be done one by one. I am interested in getting it all done, much faster

How do I make Cohesive Color Palettes on Aseprite?

To add to BloodRaven’s post: Changing the hue for the darks and lights is called “hue shifting”. You’ll generally want to pick consistent hues for this. The hue your lights shift towards will read as your light source’s colour, and the hue your darks shift towards will read as your ambient light colour. It’s common to use a warm main light and a purplish ambient colour because these work decently well in most scenarios a game will have, which saves the artist the trouble of making differently…

Mind rephrasing the question?
You want to make a palette from a sprite then extend/add more in-between colors to the palette?