Is it possible to increase palette size above 256?

Is it possible to have more than 256 colors on my palette? Otherwise i will have to switch softwares or reduce the number of colors i use.

Im working on a big project where 1024 different sprites will make a mosaic of one big 32x32 sprite. I’m going to have much more than 256 colors on my mosaic.

Does it matter if I go above 256 colors?

It’s only an issue if you’re using indexed mode and trying to import all of your sprites into one image, or if you’re trying to use over 256 in a single sprite.