Currently xp pen doesnt support asesprite it would be amazing if the team could make it work somehow.
Sorry I don’t know these XP-Pens, do you know if they offer a wintab driver? are you on Windows? which version? Can you give a try to –disable-wintab option just to see how Aseprite works without using the wintab driver (just in case XP-Pens offer a wintab driver).